Gastric gastrointestinal stromal tumors (GISTs) are the most common\nsarcoma of the gastrointestinal tract, and surgical resection is\nthe primary treatment of early disease. Limited data exist concerning\nlaparoscopic resections of these neoplasms. This systematic review\nwas designed to evaluate the literature comparing laparoscopic and\nopen surgical resection of gastric GISTs and to assess the effectiveness\nand safety of this minimally invasive technique. We performed\na systematic search of MEDLINE, the Cochrane Library, PubMed,\nEmbase, Scopus, Web of Science, Google Scholar, the clinical trials\ndatabase and ProQuest Dissertations and Theses as well as the\npast 3 years of conference abstracts from the Society of American\nGastrointestinal and Endoscopic Surgeons Annual Meetings. Studies\ncomparing the open and the laparoscopic approaches to the resection\nof gastric GISTs were included in this systematic review. Two reviewers\nindependently performed the screen of titles and abstracts, the full\nmanuscript review, the data extraction and the risk of bias assessment.\nA quantitative analysis was performed. Of the 189 studies identi�¿ed,\nseven studies were included. The laparoscopic approach was associated\nwith a signi�¿ cantly lower length of hospital stay (3.82 days (2.14\n- 5.49)). There was no observed difference in operative time, adverse\nevents, estimated blood loss, overall survival and recurrence rates.\nThis study supports that laparoscopic resection is safe and effective\nfor gastric GISTs and is associated with a signi�¿ cantly lower length of\nhospital stay. Further trials are needed for cost analysis and to rigorously\nassess oncologic outcomes.
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